Aging and Brain Research

Aging is a natural process that all living things have to go through. It is characterized by the gradual loss of function and stability at the molecular, cellular, tissue, and organ levels. This process is often accompanied by the development of age-related diseases, such as cardiovascular disease, musculoskeletal issues, neurodegenerative diseases, and cancer. During the COVID-19 pandemic, the relationship between aging and the immune system became particularly important, as older individuals have a higher risk of developing serious complications and death from the virus compared to younger people. However, there have also been reports of 100-year-old individuals who have successfully survived COVID-19 (some mentioned in our recent paper ). The rate of aging and life expectancy can be influenced by various factors, including genetics, which is believed to account for up to 30% of the variation in human lifespan. It has been found that siblings of people who have lived beyond the age o...

Age was found to be the most important characteristic associated with the risk of post-booster COVID-19 death  (panel A)  with an HR of 31.3 (95% CI, 26.1-37.6) for an 80-year-old individual compared with a 50-year-old.   Most of the risk groups were associated with an increased HR of post booster breakthrough death, except for congenital heart disease, asthma, and prior fracture. We note that asthma was identified as a risk factor after two doses, while age was not - likely because antibody response studies were focusing on younger cohorts.   This study population included those aged 18 to 100 years living in England who had completed both doses of their primary vaccination schedule and had received their mRNA booster 14 days or more prior to December 31, 2021. REFERENCES Nafilyan V, Ward IL, Robertson C, Sheikh A, National Core Studies—Immunology Breakthrough Consortium. Evaluation of Risk Factors for Postbooster Omicron COVID-19 Deaths in England....